current stimulator digitimer ds4 Search Results


ds4  (AutoMate Scientific Inc)
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low toxicity silicone adhesive  (World Precision Instruments)
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biphasic current stimulator  (Digitimer North America LLC)
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ds4 bi-phasic stimulus isolator  (Digitimer Ltd)
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arbitrary function generator tektronix afg1062  (Tektronix inc)
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function generator  (Keysight Technologies)
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twisted bipolar stimulating electrode  (PlasticsOne inc)
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PlasticsOne inc twisted bipolar stimulating electrode
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twisted bipolar stimulating electrode plastics one  (PlasticsOne inc)
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PlasticsOne inc twisted bipolar stimulating electrode plastics one
Characterizing optogenetic patch stimulation on striatal dopamine release. ( a ) Experimental design. Sepw1 NP67 mice were injected with AAV5 driving Cre-dependent expression of ChR2-eYFP. Fast-scan cyclic voltammetry was used to monitor real-time changes in dopamine levels in striatum. An electrical <t>stimulating</t> electrode was placed in the pedunculopontine nucleus (PPTg) to drive increases in dopamine in the dorsal striatum. A fiber optic was placed above patch terminals in the substantia nigra pars compacta (SNc). Electrical or optogenetic or both stimulation types were randomly selected and delivered a minimum of three times each (see Methods). ( b ) (left) Representative recording of electrical stimulation of PPTg. Here, a line shows recorded current relative to stimulation delivery (straight line below current trace) above a pseudo-color plot. The color plot shows current collected (in color) at each waveform scan (y-axis) and across time (x-axis). INSET: a “cyclic voltammogram” collected at the vertical white dotted line on the pseudo-color plot suggesting that dopamine is the predominant analyte being monitored. (right) Same as left, but optogenetic stimulation of patch terminals occurs simultaneously with PPTg electrical stimulation. ( c ) Average responses across replicates for each of the three stimulation types. PPTg stimulation only denoted as E Stim, optogenetic stimulation of patch terminals as Opto. ( d ) Maximum recorded current during stimulation normalized to electrical PPTg stimulation. ( e ) Average cyclic voltammogram across replicates for each stimulation type. * p < 0.05; ** p < 0.01; *** p < 0.001; error bars, SEM. ( a ) drawn in Illustrator CC 2019 (Adobe).
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ds-5 stimulator  (Digitimer Ltd)
90
Digitimer Ltd ds-5 stimulator
Characterizing optogenetic patch stimulation on striatal dopamine release. ( a ) Experimental design. Sepw1 NP67 mice were injected with AAV5 driving Cre-dependent expression of ChR2-eYFP. Fast-scan cyclic voltammetry was used to monitor real-time changes in dopamine levels in striatum. An electrical <t>stimulating</t> electrode was placed in the pedunculopontine nucleus (PPTg) to drive increases in dopamine in the dorsal striatum. A fiber optic was placed above patch terminals in the substantia nigra pars compacta (SNc). Electrical or optogenetic or both stimulation types were randomly selected and delivered a minimum of three times each (see Methods). ( b ) (left) Representative recording of electrical stimulation of PPTg. Here, a line shows recorded current relative to stimulation delivery (straight line below current trace) above a pseudo-color plot. The color plot shows current collected (in color) at each waveform scan (y-axis) and across time (x-axis). INSET: a “cyclic voltammogram” collected at the vertical white dotted line on the pseudo-color plot suggesting that dopamine is the predominant analyte being monitored. (right) Same as left, but optogenetic stimulation of patch terminals occurs simultaneously with PPTg electrical stimulation. ( c ) Average responses across replicates for each of the three stimulation types. PPTg stimulation only denoted as E Stim, optogenetic stimulation of patch terminals as Opto. ( d ) Maximum recorded current during stimulation normalized to electrical PPTg stimulation. ( e ) Average cyclic voltammogram across replicates for each stimulation type. * p < 0.05; ** p < 0.01; *** p < 0.001; error bars, SEM. ( a ) drawn in Illustrator CC 2019 (Adobe).
Ds 5 Stimulator, supplied by Digitimer Ltd, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Characterizing optogenetic patch stimulation on striatal dopamine release. ( a ) Experimental design. Sepw1 NP67 mice were injected with AAV5 driving Cre-dependent expression of ChR2-eYFP. Fast-scan cyclic voltammetry was used to monitor real-time changes in dopamine levels in striatum. An electrical stimulating electrode was placed in the pedunculopontine nucleus (PPTg) to drive increases in dopamine in the dorsal striatum. A fiber optic was placed above patch terminals in the substantia nigra pars compacta (SNc). Electrical or optogenetic or both stimulation types were randomly selected and delivered a minimum of three times each (see Methods). ( b ) (left) Representative recording of electrical stimulation of PPTg. Here, a line shows recorded current relative to stimulation delivery (straight line below current trace) above a pseudo-color plot. The color plot shows current collected (in color) at each waveform scan (y-axis) and across time (x-axis). INSET: a “cyclic voltammogram” collected at the vertical white dotted line on the pseudo-color plot suggesting that dopamine is the predominant analyte being monitored. (right) Same as left, but optogenetic stimulation of patch terminals occurs simultaneously with PPTg electrical stimulation. ( c ) Average responses across replicates for each of the three stimulation types. PPTg stimulation only denoted as E Stim, optogenetic stimulation of patch terminals as Opto. ( d ) Maximum recorded current during stimulation normalized to electrical PPTg stimulation. ( e ) Average cyclic voltammogram across replicates for each stimulation type. * p < 0.05; ** p < 0.01; *** p < 0.001; error bars, SEM. ( a ) drawn in Illustrator CC 2019 (Adobe).

Journal: Scientific Reports

Article Title: Optogenetic stimulation of striatal patches modifies habit formation and inhibits dopamine release

doi: 10.1038/s41598-021-99350-5

Figure Lengend Snippet: Characterizing optogenetic patch stimulation on striatal dopamine release. ( a ) Experimental design. Sepw1 NP67 mice were injected with AAV5 driving Cre-dependent expression of ChR2-eYFP. Fast-scan cyclic voltammetry was used to monitor real-time changes in dopamine levels in striatum. An electrical stimulating electrode was placed in the pedunculopontine nucleus (PPTg) to drive increases in dopamine in the dorsal striatum. A fiber optic was placed above patch terminals in the substantia nigra pars compacta (SNc). Electrical or optogenetic or both stimulation types were randomly selected and delivered a minimum of three times each (see Methods). ( b ) (left) Representative recording of electrical stimulation of PPTg. Here, a line shows recorded current relative to stimulation delivery (straight line below current trace) above a pseudo-color plot. The color plot shows current collected (in color) at each waveform scan (y-axis) and across time (x-axis). INSET: a “cyclic voltammogram” collected at the vertical white dotted line on the pseudo-color plot suggesting that dopamine is the predominant analyte being monitored. (right) Same as left, but optogenetic stimulation of patch terminals occurs simultaneously with PPTg electrical stimulation. ( c ) Average responses across replicates for each of the three stimulation types. PPTg stimulation only denoted as E Stim, optogenetic stimulation of patch terminals as Opto. ( d ) Maximum recorded current during stimulation normalized to electrical PPTg stimulation. ( e ) Average cyclic voltammogram across replicates for each stimulation type. * p < 0.05; ** p < 0.01; *** p < 0.001; error bars, SEM. ( a ) drawn in Illustrator CC 2019 (Adobe).

Article Snippet: A twisted bipolar stimulating electrode (Plastics One, Roanoke, VA, USA) connected to a DS4 Biphasic Constant Current Stimulus Isolator (Digitimer) was lowered in 0.1-mm increments starting at − 1.5 DV into PPTg until robust dopamine increases were detected in the dorsal striatum.

Techniques: Injection, Expressing